Quantitative Structure-Activity Relationships for Polychlorinated Hydroxybiphenyl Estrogen Receptor Binding Affinity : An Assessment of Conformer Flexibility

A diverse group of xenobiotics has a high binding affinity to the estrogen receptor (ER), suggesting that it can accommodate large variability in ligand structure. Relationships between xenobiotic structure, binding affinity, and estrogenic response have been suggested to be dependent on the conformational structures of the ligands. To explore the influence… CONTINUE READING