Quantitative Structure‐Activity Relationships of Perfluorinated Hetero‐Hydrocarbons as Potential Respiratory Media: Application to Oxygen Solubility, Partition Coefficient, Viscosity, Vapor Pressure, and Density

  title={Quantitative Structure‐Activity Relationships of Perfluorinated Hetero‐Hydrocarbons as Potential Respiratory Media: Application to Oxygen Solubility, Partition Coefficient, Viscosity, Vapor Pressure, and Density},
  author={Jerome L. Gabriel and Timothy Francis Miller and Marla R. Wolfson and T. H. Shaffer},
  journal={ASAIO Journal},
&NA; It has been extensively reported that liquid‐assisted ventilation, using inert perfluorocarbon liquids (PFCs), can reduce interfacial surface tension and allow for improved ventilation at decreased alveolar pressures. PFCs are bioinert, minimally absorbed, and have no deleterious histologic, cellular, or biochemical effects when used as respiratory media. Although several types of PFCs have been characterized, a select few are considered to be compatible with life. Compatibility is often… 
Prediction of aqueous solubility, vapor pressure and critical micelle concentration for aquatic partitioning of perfluorinated chemicals.
The majority of perfluorinated chemicals (PFCs) are of increasing risk to biota and environment due to their physicochemical stability, wide transport in the environment and difficulty in
Differential impact of perfluorochemical physical properties on the physiologic, histologic, and inflammatory profile in acute lung injury
PLV, with a single dose of higher viscosity and lower vapor pressure PFC, resulted in significantly improved gas exchange and lung mechanics with significant reduction in lung inflammation compared with conventional mechanical ventilation alone and PLV with lower viscosities and higher vapor pressure liquid.
Anti-inflammatory effects of perfluorocarbon compounds
  • H. Lehmler
  • Biology, Medicine
    Expert review of respiratory medicine
  • 2008
Perfluorocarbon compounds (PFCs) are of interest for the treatment of acute lung injury due to unique physicochemical properties such as high solubility for oxygen. Different respiratory treatment
Liquid ventilation: Gas exchange, perfluorochemical uptake, and biodistribution in an acute lung injury
In severe lung injury, this study demonstrates that physiologic gas exchange can be maintained with TLV or PLV, and perfluorochemical fluid in the blood and tissue is low during PLV and TLV relative to that associated with intravenous administration of perfluarochemical fluid emulsion.
Effect of single versus multiple dosing on perfluorochemical distribution and elimination during partial liquid ventilation
The objective of this study was to quantitate perfluorochemical (PFC) elimination kinetics during partial liquid ventilation (PLV) following an initial fill with or without hourly dosing, and to calculate PFC elimination calculations.
Modelling of noble anaesthetic gases and high hydrostatic pressure effects in lipid bilayers.
The irregular lipid headgroup-water boundary observed in DOPC bilayers saturated with neon in the pressure range of 1-100 bar could be associated with the possible manifestation of neurological tremors at the atomic scale, which supports the 'critical volume' hypothesis of anaesthesia pressure reversal.
Perfluorocarbon compounds as vehicles for pulmonary drug delivery
  • H. Lehmler
  • Biology, Chemistry
    Expert opinion on drug delivery
  • 2007
Drug delivery to the diseased lung is hindered by the buildup of fluid and shunting of blood flow away from the site of injury, so several approaches, such as dispersions, prodrugs, solubilizing agents and (micro)emulsions, are under investigation to develop homogeneous PFC–drug mixtures suitable for intrapulmonary administration.
Perfluorochemical liquids modulate cell-mediated inflammatory responses
At PFC concentrations comparable with those in blood during liquid ventilation, PFC liquids did not induce variables associated with inflammation.
Measurements of Evaporated Perfluorocarbon during Partial Liquid Ventilation by a Zeolite Absorber
PFC selective zeolites can be used to quantify accurately the evaporated PFC volume during PLV and under steady state conditions there was a strong correlation between the infusion speed of PFC and the calculated PFC flow rate.