Quantitative Profiling of Prostaglandins and Thromboxane B 2 Measured in PRP by High - Resolution Gas Table 2 . Effect of Dazoxiben on Platelet Aggregation

Abstract

Dazoxiben. an imidazole-derived selective inhibitor of thromboxane A2 (TxA2) synthetase, prevented TxB2 synthesis in vitro in platelet-rich plasma from 1 6 normal subjects. Inhibition of TxB2 synthesis was accompanied by increased generation of PGE2. PGF ,. and PGD2. as shown by radioimmunoassay. thin-layer radiochromatography, and high-resolution gas chromatography-mass spectrometry. Even at dazoxiben concentrations (40-80 M) above those inhibiting TxB2 synthesis, platelet aggregation induced by threshold concentrations of arachidonic acid was inhibited in only 4 of 1 6 subjects. referred to as responders. The remaining 12 individuals were defined as nonresponders. The aggregating effect of arachidonic acid and of the prostaglandin-endoperoxide analog U-4661 9

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Cite this paper

@inproceedings{Tomasiak2005QuantitativePO, title={Quantitative Profiling of Prostaglandins and Thromboxane B 2 Measured in PRP by High - Resolution Gas Table 2 . Effect of Dazoxiben on Platelet Aggregation}, author={Maria Magdalena Tomasiak and Chiara Chiabrando and Chiara Cerletti and Giovanni de Gaetano and Mario Negri}, year={2005} }