Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser280 by Hallucinogenic versus Nonhallucinogenic Agonists*

@article{Karaki2014QuantitativePU,
  title={Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser280 by Hallucinogenic versus Nonhallucinogenic Agonists*},
  author={Samah Karaki and Carine B{\'e}camel and Samy Murat and Clotilde Mannoury la Cour and Mark J. Millan and Laurent Prezèau and Joël Bockaert and Philippe Marin and Franck Vandermoere},
  journal={Molecular & Cellular Proteomics : MCP},
  year={2014},
  volume={13},
  pages={1273 - 1285}
}
  • Samah Karaki, Carine Bécamel, +6 authors Franck Vandermoere
  • Published 2014
  • Medicine, Biology
  • Molecular & Cellular Proteomics : MCP
  • The serotonin 5-HT2A receptor is a primary target of psychedelic hallucinogens such as lysergic acid diethylamine, mescaline, and psilocybin, which reproduce some of the core symptoms of schizophrenia. An incompletely resolved paradox is that only some 5-HT2A receptor agonists exhibit hallucinogenic activity, whereas structurally related agonists with comparable affinity and activity lack such a psychoactive activity. Using a strategy combining stable isotope labeling by amino acids in cell… CONTINUE READING

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    Serotonin and Hallucinogens