Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

  title={Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis},
  author={Jesper V. Olsen and Michiel Vermeulen and Anna Santamar{\'i}a and Chanchal Kumar and Martin L. Miller and Lars Juhl Jensen and Florian Gnad and J{\"u}rgen Cox and Thomas Sk{\o}t Jensen and Erich A. Nigg and S{\o}ren Brunak and Matthias Mann},
  journal={Science Signaling},
  pages={ra3 - ra3}
Protein phosphorylation during the cell cycle may be an all-or-none process in many instances. All-or-None Phosphorylation Phosphorylation is a key regulatory event that drives many cellular processes, including cell division. Olsen et al. undertook a phosphoproteomic analysis of HeLa cells at various stages in the cell cycle, which linked new phosphorylation sites and kinase substrates to specific stages. Furthermore, they established a method to calculate the fractional occupancy of… 

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