Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen

@article{Shu2009QuantitativePR,
  title={Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen},
  author={Chengyi Jenny Shu and Caius G Radu and Stephanie M. Shelly and Dan D. Vo and Robert M. Prins and Antoni Ribas and Michael E. Phelps and Owen N Witte},
  journal={International Immunology},
  year={2009},
  volume={21},
  pages={155 - 165}
}
Adoptive transfer (AT) T-cell therapy provides significant clinical benefits in patients with advanced melanoma. However, approaches to non-invasively visualize the persistence of transferred T cells are lacking. We examined whether positron emission tomography (PET) can monitor the distribution of self-antigen-specific T cells engineered to express an herpes simplex virus 1 thymidine kinase (sr39tk) PET reporter gene. Micro-PET imaging using the sr39tk-specific substrate 9-[4-[(18)F]fluoro-3… CONTINUE READING