Quantitative PET Studies of the Serotonin Transporter in MDMA Users and Controls Using [11C]McN5652 and [11C]DASB

@article{McCann2005QuantitativePS,
  title={Quantitative PET Studies of the Serotonin Transporter in MDMA Users and Controls Using [11C]McN5652 and [11C]DASB},
  author={Una D. McCann and Zsolt Szabo and Esen Seckin and Peter Rosenblatt and William B Mathews and Hayden T. Ravert and Robert F. Dannals and George A. Ricaurte},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={1741-1750}
}
(±)3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) is a widely used illicit drug that produces toxic effects on brain serotonin axons and axon terminals in animals. The results of clinical studies addressing MDMA's serotonin neurotoxic potential in humans have been inconclusive. In the present study, 23 abstinent MDMA users and 19 non-MDMA controls underwent quantitative positron emission tomography (PET) studies using [11C]McN5652 and [11C]DASB, first- and second-generation serotonin… CONTINUE READING
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