Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis

@article{Ishige1999QuantitativePO,
  title={Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis},
  author={Ikuo Ishige and Yutaka Usui and Tamiko Takemura and Yoshinobu Eishi},
  journal={The Lancet},
  year={1999},
  volume={354},
  pages={120-123}
}
BACKGROUND The causes of sarcoidosis are not known. The DNA of Mycobacterium tuberculosis has been detected in some sarcoid lesions. In Japan, Propionibacterium acnes has been isolated from such lesions, but whether this indigenous bacterium is related to the disease is unclear. We used PCR to estimate the number of genomes of these bacteria in sarcoid lesions, to identify any link between sarcoidosis and these two bacterial species. METHODS We examined formalin-fixed and paraffin-embedded… CONTINUE READING
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