Quantitative Nanoscopy of Inhibitory Synapses: Counting Gephyrin Molecules and Receptor Binding Sites

@article{Specht2013QuantitativeNO,
  title={Quantitative Nanoscopy of Inhibitory Synapses: Counting Gephyrin Molecules and Receptor Binding Sites},
  author={Christian G Specht and Ignacio Izeddin and Pamela C. Rodriguez and Mohamed El Beheiry and Philippe Rostaing and Xavier Darzacq and Maxime Dahan and Antoine Triller},
  journal={Neuron},
  year={2013},
  volume={79},
  pages={308-321}
}
The strength of synaptic transmission is controlled by the number and activity of neurotransmitter receptors. However, little is known about absolute numbers and densities of receptor and scaffold proteins and the stoichiometry of molecular interactions at synapses. Here, we conducted three-dimensional and quantitative nanoscopic imaging based on single-molecule detections to characterize the ultrastructure of inhibitory synapses and to count scaffold proteins and receptor binding sites. We… CONTINUE READING
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