Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

@article{Schena1995QuantitativeMO,
  title={Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray},
  author={M. Schena and D. Shalon and Ronald W. Davis and P. Brown},
  journal={Science},
  year={1995},
  volume={270},
  pages={467 - 470}
}
A high-capacity system was developed to monitor the expression of many genes in parallel. Microarrays prepared by high-speed robotic printing of complementary DNAs on glass were used for quantitative expression measurements of the corresponding genes. Because of the small format and high density of the arrays, hybridization volumes of 2 microliters could be used that enabled detection of rare transcripts in probe mixtures derived from 2 micrograms of total cellular messenger RNA. Differential… Expand

Paper Mentions

Interventional Clinical Trial
This study is designed to determine whether molecular detection of breast cancer cells in the peripheral blood of Stage IV breast cancer patients is a clinically relevant predictor of… Expand
ConditionsBreast Neoplasms
InterventionOther
Observational Clinical Trial
This study will examine blood cells and other tissue samples from people with uveitis (eye inflammation) to try to gain a better understanding of this condition. It will look at 1) the… Expand
ConditionsOcular Inflammatory Disease, Uveitis
Genome analysis with gene expression microarrays.
  • M. Schena
  • Biology, Medicine
  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1996
Preparation of mRNA for Expression Monitoring
Preparation of mRNA for Expression Monitoring
FOR THE ANALYSIS OF GENE EXPRESSION
Yeast microarrays for genome wide parallel genetic and gene expression analysis.
Using array hybridization to monitor gene expression at the single cell level.
Novel developments for improved detection of specific mRNAs by DNA chips
Monitoring gene expression using DNA microarrays.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Characterization of the genome of Arabidopsis thaliana.
An inventory of 1152 expressed sequence tags obtained by partial sequencing of cDNAs from Arabidopsis thaliana.
Identification and map position of YAC clones comprising one-third of the Arabidopsis genome.
Arabidopsis thaliana and Plant Molecular Genetics
HD-Zip proteins: members of an Arabidopsis homeodomain protein superfamily.
  • M. Schena, R. W. Davis
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
The HAT4 gene of Arabidopsis encodes a developmental regulator.
...
1
2
...