Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. elegans Sensory Behaviors

@article{McGrath2009QuantitativeMO,
  title={Quantitative Mapping of a Digenic Behavioral Trait Implicates Globin Variation in C. elegans Sensory Behaviors},
  author={Patrick T McGrath and Matthew V Rockman and Manuel Zimmer and Heeun Jang and Evan Z Macosko and Leonid Kruglyak and Cornelia I Bargmann},
  journal={Neuron},
  year={2009},
  volume={61},
  pages={692-699}
}
Most heritable behavioral traits have a complex genetic basis, but few multigenic traits are understood at a molecular level. Here we show that the C. elegans strains N2 and CB4856 have opposite behavioral responses to simultaneous changes in environmental O(2) and CO(2). We identify two quantitative trait loci (QTL) that affect this trait and map each QTL to a single-gene polymorphism. One gene, npr-1, encodes a previously described neuropeptide receptor whose high activity in N2 promotes CO(2… CONTINUE READING
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