Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis.

@article{Blezer2007QuantitativeMC,
  title={Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis.},
  author={Erwin L. A. Blezer and Jan Niklas Bauer and Herbert P. M. Brok and Klaas Nicolay and Bert A 't Hart},
  journal={NMR in biomedicine},
  year={2007},
  volume={20 2},
  pages={90-103}
}
Experimental autoimmune encephalomyelitis (EAE) induced with recombinant human myelin/oligodendrocyte glycoprotein in the common marmoset is a useful preclinical model of multiple sclerosis in which white matter lesions can be well visualized with MRI. In this study we characterized lesion progression with quantitative in vivo MRI (4.7 T; T(1) relaxation time +/- Gd-DTPA; T(2) relaxation time; magnetization transfer ratio, MTR, imaging) and correlated end stage MRI presentation with… CONTINUE READING
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