Quantitative MRI of the spinal cord and brain in adrenomyeloneuropathy: in vivo assessment of structural changes.

@article{Castellano2016QuantitativeMO,
  title={Quantitative MRI of the spinal cord and brain in adrenomyeloneuropathy: in vivo assessment of structural changes.},
  author={Antonella Castellano and Nico Papinutto and Marcello Cadioli and G Brugnara and Antonella Iadanza and Graziana Maria Scigliuolo and Davide Pareyson and Graziella Uziel and Wolfgang R. K{\"o}hler and Patrick A Aubourg and Andrea Falini and Roland G. Henry and Letterio Salvatore Politi and Ettore Salsano},
  journal={Brain : a journal of neurology},
  year={2016},
  volume={139 Pt 6},
  pages={1735-46}
}
Adrenomyeloneuropathy is the late-onset form of X-linked adrenoleukodystrophy, and is considered the most frequent metabolic hereditary spastic paraplegia. In adrenomyeloneuropathy the spinal cord is the main site of pathology. Differently from quantitative magnetic resonance imaging of the brain, little is known about the feasibility and utility of advanced neuroimaging in quantifying the spinal cord abnormalities in hereditary diseases. Moreover, little is known about the subtle pathological… CONTINUE READING
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