• Corpus ID: 54082099

Quantitative Gas Chromatographic Analysis of [ 1-( 4-Pi pe rid i nyl )-1 3-d i hyd ro-2 H-benzim idaz ole-2one ] , / the Basic Metabollte of Bezitramide ( Burgodin | in Human Urine

@inproceedings{Baere2012QuantitativeGC,
  title={Quantitative Gas Chromatographic Analysis of [ 1-( 4-Pi pe rid i nyl )-1 3-d i hyd ro-2 H-benzim idaz ole-2one ] , / the Basic Metabollte of Bezitramide ( Burgodin | in Human Urine},
  author={Miet De Baere and Willy E E Lambert and Pack De},
  year={2012}
}
A gas chromatographic procedure with nitrogen-phosphorus detection was developed for the quantitative determination of 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one, the basic metabolite of the narcotic analgesic bezitramide (Burgodin), in urine. Gas chromatography with mass spectrometric detection was used for confirmation. An internal standard with great structural resemblance to the basic metabolite was synthesized in our laboratory. For the isolation of the compound from urine, a… 

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