Quantitative Gas Chromatographic Analysis of [ 1-( 4-Pi pe rid i nyl )-1 3-d i hyd ro-2 H-benzim idaz ole-2one ] , / the Basic Metabollte of Bezitramide ( Burgodin | in Human Urine
@inproceedings{Baere2012QuantitativeGC, title={Quantitative Gas Chromatographic Analysis of [ 1-( 4-Pi pe rid i nyl )-1 3-d i hyd ro-2 H-benzim idaz ole-2one ] , / the Basic Metabollte of Bezitramide ( Burgodin | in Human Urine}, author={M. D. Baere and W. Lambert and P. De}, year={2012} }
A gas chromatographic procedure with nitrogen-phosphorus detection was developed for the quantitative determination of 1-(4-piperidinyl)-1,3-dihydro-2H-benzimidazole-2-one, the basic metabolite of the narcotic analgesic bezitramide (Burgodin), in urine. Gas chromatography with mass spectrometric detection was used for confirmation. An internal standard with great structural resemblance to the basic metabolite was synthesized in our laboratory. For the isolation of the compound from urine, a… CONTINUE READING
Figures and Tables from this paper
References
SHOWING 1-10 OF 16 REFERENCES
Quantitative gas chromatographic analysis of 3-cyano-3,3-diphenylpropionic acid, the acidic metabolite of bezitramide (Burgodin), in urine.
- Medicine, Chemistry
- Journal of analytical toxicology
- 1996
- 5
- PDF
Pharmacokinetics of the oral narcotic analgesic bezitramide and preliminary observations on its effect on experimentally induced pain
- Medicine
- European Journal of Clinical Pharmacology
- 2004
- 4
Determination of the metabolites of bezitramide in urine. I. Acidic metabolite.
- Chemistry, Medicine
- Journal of chromatography
- 1978
- 12
Benzimidazol-Derivate und verwandte Heterocyclen. IV. Die Kondensation von o-Phenylendiamin mit α-Aryl- und γ-Aryl-acetessigester
- Chemistry
- 1960
- 22
THE VALIDATION CRITERIA FOR ANALYTICAL METHODS USED IN PHARMACY PRACTICE RESEARCH
- Medicine
- Journal of clinical pharmacy and therapeutics
- 1989
- 34
Determination of the metabolites of bezitramide in urine
- Acidic metabolite. J. Chromatogr
- 1978