Quantitative Flow Measurements in Bioreactors by Nuclear Magnetic Resonance Imaging

@article{Hammer1990QuantitativeFM,
  title={Quantitative Flow Measurements in Bioreactors by Nuclear Magnetic Resonance Imaging},
  author={Bruce E. Hammer and Carole A. Heath and Scott D. Mirer and Georges Belfort},
  journal={Bio/Technology},
  year={1990},
  volume={8},
  pages={327-330}
}
We have developed nuclear magnetic resonance (NMR) flow imaging techniques to measure fluid flow in a cell-free hollow fiber bioreactor (HFBR). Using 1H NMR we track the motion of protons and obtain velocity distributions as a function of position and time. These measurements enable the visualization of flow patterns needed for module design and for establishing desired operating conditions. Uneven flow in the cell-containing region of an HFBR can result in concentration gradients and uneven… CONTINUE READING