Quantitative Evaluation of the Drug-Drug Interactions between Methotrexate and Nonsteroidal Anti-Inflammatory Drugs in the Renal Uptake Process Based on the Contribution of Organic Anion Transporters and Reduced Folate Carrier

@article{Nozaki2004QuantitativeEO,
  title={Quantitative Evaluation of the Drug-Drug Interactions between Methotrexate and Nonsteroidal Anti-Inflammatory Drugs in the Renal Uptake Process Based on the Contribution of Organic Anion Transporters and Reduced Folate Carrier},
  author={Yoshitane Nozaki and H. Kusuhara and H. Endou and Y. Sugiyama},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2004},
  volume={309},
  pages={226 - 234}
}
  • Yoshitane Nozaki, H. Kusuhara, +1 author Y. Sugiyama
  • Published 2004
  • Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
  • The present study examined the possible role of transporters in the drug-drug interactions between methotrexate (MTX) and nonsteroidal anti-inflammatory drugs (NSAIDs) in the renal uptake process of MTX. MTX is recognized by reduced folate carrier (RFC-1) and rat organic anion transporters (rOat1 and rOat3) as a substrate. Uptake of MTX by kidney slices was saturable and inhibited potently by dibromosulfophthalein. Folate and benzylpenicillin (PCG) inhibited the uptake by 30 to 40% and 40 to 50… CONTINUE READING
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