Quantitative Description of Glycan-Receptor Binding of Influenza A Virus H7 Hemagglutinin

  title={Quantitative Description of Glycan-Receptor Binding of Influenza A Virus H7 Hemagglutinin},
  author={Karunya Srinivasan and Rahul Raman and Akila Jayaraman and K. Kuperan Viswanathan and Ram Sasisekharan},
  booktitle={PloS one},
In the context of recently emerged novel influenza strains through reassortment, avian influenza subtypes such as H5N1, H7N7, H7N2, H7N3 and H9N2 pose a constant threat in terms of their adaptation to the human host. Among these subtypes, it was recently demonstrated that mutations in H5 and H9 hemagglutinin (HA) in the context of lab-generated reassorted viruses conferred aerosol transmissibility in ferrets (a property shared by human adapted viruses). We previously demonstrated that the… CONTINUE READING
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Experimental adaptation of an influenza H 5 HA confers respiratory droplet transmission to a reassortant H 5 HA / H 1 N 1 virus in ferrets

  • M Imai, T Watanabe, M Hatta, SC Das, M Ozawa
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