Quantitative DNA fiber mapping.

  title={Quantitative DNA fiber mapping.},
  author={H U Weier and Minxiu Wang and James C. Mullikin and Y. Zhu and J. F. Cheng and Katharina Greulich and Aaron Bensimon and Joe W. Gray},
  journal={Human molecular genetics},
  volume={4 10},
The assembly of sequence ready, high-resolution physical maps and construction of minimally overlapping contigs for the human as well as model genomes requires accurate determination of the extent of overlap between adjacent clones as well as their relative orientation. This is presently done by procedures such as clone fingerprinting, Southern blot analysis or clone end sequencing. We present a complementary analytical technique to map directly cloned DNA sequences on to individual stretched… CONTINUE READING


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