Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk

  title={Quantitative Assessment of Common Genetic Variants on FOXE1 and Differentiated Thyroid Cancer Risk},
  author={Hongling Zhu and Qian Xi and Lianyong Liu and Jingnan Wang and Mingjun Gu},
  journal={PLoS ONE},
Forkhead box E1 encodes the transcription factor FOXE1 (or TTF-2), which together with Homeobox protein NKX2-1, PAX8 and HHEX, are pivotal proteins required for thyroid gland formation, differentiation and function. Recently, genome-wide association studies have identified FOXE1 as a thyroid cancer (TC) susceptibility gene in populations of European descent. After that, a number of studies reported that the rs965513, rs1867277, and rs71369530 polymorphism in FOXE1 has been implicated in TC risk… 

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