Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids.

@article{Neinast2019QuantitativeAO,
  title={Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids.},
  author={Michael D. Neinast and Cholsoon Jang and Sheng Hui and Danielle S. Murashige and Qingwei Chu and Raphael J. Morscher and Xiaoxuan Li and Le Zhan and Eileen P. White and Tracy G Anthony and Joshua D. Rabinowitz and Zoltan Arany},
  journal={Cell metabolism},
  year={2019},
  volume={29 2},
  pages={
          417-429.e4
        }
}
Elevations in branched-chain amino acids (BCAAs) associate with numerous systemic diseases, including cancer, diabetes, and heart failure. However, an integrated understanding of whole-body BCAA metabolism remains lacking. Here, we employ in vivo isotopic tracing to systemically quantify BCAA oxidation in healthy and insulin-resistant mice. We find that most tissues rapidly oxidize BCAAs into the tricarboxylic acid (TCA) cycle, with the greatest quantity occurring in muscle, brown fat, liver… CONTINUE READING
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