Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease.

@article{Subramanian2017QuantitativeAO,
  title={Quantitative Analysis of the Proteome Response to the Histone Deacetylase Inhibitor (HDACi) Vorinostat in Niemann-Pick Type C1 disease.},
  author={Kanagaraj Subramanian and Navin Rauniyar and Mathieu Lavall{\'e}e-Adam and John R. Yates and William E. Balch},
  journal={Molecular & cellular proteomics : MCP},
  year={2017},
  volume={16 11},
  pages={
          1938-1957
        }
}
Niemann-Pick type C (NPC) disease is an inherited, progressive neurodegenerative disorder principally caused by mutations in the NPC1 gene. NPC disease is characterized by the accumulation of unesterified cholesterol in the late endosomes (LE) and lysosomes (Ly) (LE/Ly). Vorinostat, a histone deacetylase inhibitor (HDACi), restores cholesterol homeostasis… CONTINUE READING