Quantitative Analysis of Plasma TP53 249-Mutated DNA by Electrospray Ionization Mass Spectrometry

Abstract

A mutation in codon 249 of the TP53 gene (249), related to aflatoxin B1 exposure, has previously been associated with hepatocellular carcinoma risk. Using a novel internal standard plasmid, plasma concentrations of 249-mutated DNA were quantified by electrospray ionization mass spectrometry in 89 hepatocellular carcinoma cases, 42 cirrhotic patients, and… (More)

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Lleonart2005QuantitativeAO, title={Quantitative Analysis of Plasma TP53 249-Mutated DNA by Electrospray Ionization Mass Spectrometry}, author={Matilde E L Lleonart and Gregory D Kirk and St{\'e}phanie Villar and Olufunmilayo Adenike Lesi and A. Dasgupta and James Jerome Goedert and Maimuna E. Mendy and M. Hollstein and Ruggero Montesano and John D. Groopman and Pierre Hainaut and Marlin D. Friesen}, year={2005} }