Quantitative Analysis of MicroRNAs in Vaccinia virus Infection Reveals Diversity in Their Susceptibility to Modification and Suppression

@inproceedings{Buck2015QuantitativeAO,
  title={Quantitative Analysis of MicroRNAs in Vaccinia virus Infection Reveals Diversity in Their Susceptibility to Modification and Suppression},
  author={Amy H. Buck and Alasdair Ivens and Katrina E Gordon and Nicola Craig and Alexandre Houzelle and Alice Roche and Neil Turnbull and Philippa M. Beard and James Peter Stewart},
  booktitle={PloS one},
  year={2015}
}
Vaccinia virus (VACV) is a large cytoplasmic DNA virus that causes dramatic alterations to many cellular pathways including microRNA biogenesis. The virus encodes a poly(A) polymerase which was previously shown to add poly(A) tails to the 3' end of cellular miRNAs, resulting in their degradation by 24 hours post infection (hpi). Here we used small RNA… CONTINUE READING