Quantitative Analysis of Constitutive and 2 , 3 , 7 , 8-Tetrachlorodibenzo-p-dioxin-induced Cytochrome P 450 1 B 1 Expression in Human Lymphocytes 1

Abstract

Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) results in a broad spectrum of biological responses, including altered metabolism, disruption of normal hormone signaling pathways, reproductive and developmental effects, and cancer. Cytochrome P450 1B1 (CYP1B1) is a dioxin-inducible gene that is active in the formation of 4-hydroxyestradiol… (More)

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