Quantitative 3T MR imaging of the descending thoracic aorta: patients with familial hypercholesterolemia have an increased aortic plaque burden despite long-term lipid-lowering therapy.

@article{Schmitz2008Quantitative3M,
  title={Quantitative 3T MR imaging of the descending thoracic aorta: patients with familial hypercholesterolemia have an increased aortic plaque burden despite long-term lipid-lowering therapy.},
  author={Stephan Albert Schmitz and Declan P. O'Regan and Julie Fitzpatrick and Clare K Neuwirth and Elizabeth M Potter and Isabella Tosi and Joseph V. Hajnal and Rossitza P. Naoumova},
  journal={Journal of vascular and interventional radiology : JVIR},
  year={2008},
  volume={19 10},
  pages={
          1403-8
        }
}
PURPOSE To compare the aortic plaque burden in patients with heterozygous familial hypercholesterolemia on long-term statin treatment with that of matched control subjects. MATERIALS AND METHODS The authors studied 11 heterozygous, nonsmoking, nondiabetic, and nonhypertensive patients with familial hypercholesterolemia (mean age, 44 years +/- 10) who had been receiving cholesterol-lowering management for a mean of 12 years +/- 5, including 8.25 years +/- 4.24 with the highest tolerable doses… CONTINUE READING