Quantitative 1H MR spectroscopic imaging in early Rett syndrome.

  title={Quantitative 1H MR spectroscopic imaging in early Rett syndrome.},
  author={A Horska and Sakkubai R Naidu and E Herskovits and P. Y. Wang and Walter E. Kaufmann and Peter B. Barker},
  volume={54 3},
OBJECTIVE To determine cerebral regional concentrations of N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cr) in Rett syndrome (RS) using 1H magnetic resonance spectroscopic imaging (MRSI). BACKGROUND The biochemical defect underlying RS is unknown. Because in vivo MRSI can detect important cerebral metabolites, MRSI has a potential to reveal impairment of regional cerebral metabolism in RS noninvasively. METHODS High-resolution, multislice 1H MRSI was carried out in 17… CONTINUE READING
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