Quantitative, video-based histochemistry to measure regional effects of anticholinesterase pesticides in rat brain.

@article{Hammond1996QuantitativeVH,
  title={Quantitative, video-based histochemistry to measure regional effects of anticholinesterase pesticides in rat brain.},
  author={Pamela I. Hammond and Tanya M Jelacic and S. J. Padilla and Stephen Brimijoin},
  journal={Analytical biochemistry},
  year={1996},
  volume={241 1},
  pages={82-92}
}
Acetylcholinesterase histochemistry was coupled to inexpensive and widely available apparatus for video microscopy and densitometry to study enzyme activity and inhibition in different parts of the rat brain. Quantitative histochemistry, under properly defined conditions, yielded an output that increased linearly with incubation time and section thickness and was a smooth hyperbolic function of substrate concentration. The time-course of staining after in vivo exposure to eserine revealed no… CONTINUE READING

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