Quantitative, spectrally-resolved intraoperative fluorescence imaging

  title={Quantitative, spectrally-resolved intraoperative fluorescence imaging},
  author={Pablo Valdes and Frederic Leblond and Valerie L. Jacobs and Brian C. Wilson and Keith D. Paulsen and David W. Roberts},
  booktitle={Scientific reports},
Intraoperative visual fluorescence imaging (vFI) has emerged as a promising aid to surgical guidance, but does not fully exploit the potential of the fluorescent agents that are currently available. Here, we introduce a quantitative fluorescence imaging (qFI) approach that converts spectrally-resolved data into images of absolute fluorophore concentration pixel-by-pixel across the surgical field of view (FOV). The resulting estimates are linear, accurate, and precise relative to true values… CONTINUE READING
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first in-human results

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implications for ALA-induced PpIX as an intraoperative biomarker

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the need for quantitative fluorescence-guided resection to identify regions of increasing malignancy

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