Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline.

  title={Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline.},
  author={Jason R. Buck and Eliot T. McKinley and Matthew R. Hight and Allie Fu and Dewei Tang and Ralph Adam Smith and Mohammed Noor Tantawy and Todd E. Peterson and Daniel C Colvin and Mohammed Sib Ansari and Ronald M. Baldwin and Ping Zhao and Saffet Guleryuz and H Charles Manning},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={52 1},
UNLABELLED Translocator protein (TSPO), also referred to as peripheral benzodiazepine receptor (PBR), is a crucial 18-kDa outer mitochondrial membrane protein involved in numerous cellular functions, including the regulation of cholesterol metabolism, steroidogenesis, and apoptosis. Elevated expression of TSPO in oncology correlates with disease progression and poor survival, suggesting that molecular probes capable of assaying TSPO levels may have potential as cancer imaging biomarkers. In… CONTINUE READING
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