Quantitation of testolactone and 4,5-dihydrotestolactone in plasma and urine using high-performance liquid chromatography.

  title={Quantitation of testolactone and 4,5-dihydrotestolactone in plasma and urine using high-performance liquid chromatography.},
  author={Virginia L. Pascucci and Russell L. Yeager and Richard J. Sherins and Richard V Clark and Joseph F. Gallelli and Dulal C. Chatterji},
  journal={Journal of chromatography},
4 Citations
Determination of plasma testosterone using a simple liquid chromatographic method.
  • B. Ng, K. Yuen
  • Chemistry
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2003
Treatment of men with idiopathic oligozoospermic infertility using the aromatase inhibitor, testolactone. Results of a double-blinded, randomized, placebo-controlled trial with crossover.
The data suggest that chronic administration of testolactone at this dose fails to maintain aromatase inhibition despite depression of 17,20-desmolase activity with elevated 17 alpha-hydroxyprogesterone and depressed SHBG binding capacity with elevation of free testosterone.
Metabolism of steroid-modifying anticancer agents.
Metabolism and excretion of anabolic steroids in doping control—New steroids and new insights
  • P. Eenoo, F. Delbeke
  • Biology, Medicine
    The Journal of Steroid Biochemistry and Molecular Biology
  • 2006


Inhibition of peripheral aromatization of androstenedione to estrone in postmenopausal women with breast cancer using delta 1-testololactone.
Data are consistent with the concept that delta 1-testololactone is a potent inhibitor of peripheral aromatization of delta to E1, which could explain the antitumor properties of this compound.
Evidence that testosterone can suppress pituitary gonadotropin secretion independently of peripheral aromatization.
The hypothesis that T or one of its metabolites can modulate LH and FSH secretion independently of peripheral aromatization to E is supported, as well as the pattern of plasma steroids, increased T and unchanged E.
Effects of Ε11-Testolactone on the Pituitary-Testicular Axis In Oligospermic Men
The data suggest that Teslac may be an effective treatment for men with idiopathic oligospermia, and a potent inhibitor of conversion of androgens to estrogens.
Studies on the role of sex steroids in the feedback control of gonadotropin concentrations in men. III. Androgen resistance in primary gonadal failure.
ABSTRACT The negative feedback control of serum gonadotropins by sex steroids was studied in eight men with Leydig cell insufficiency, four of whom had diminished and four with unmeasurable Leydig