Quantitation of testolactone and 4,5-dihydrotestolactone in plasma and urine using high-performance liquid chromatography.

@article{Pascucci1983QuantitationOT,
  title={Quantitation of testolactone and 4,5-dihydrotestolactone in plasma and urine using high-performance liquid chromatography.},
  author={Virginia L. Pascucci and Russell L. Yeager and Richard J. Sherins and Richard V Clark and Joseph F. Gallelli and Dulal C. Chatterji},
  journal={Journal of chromatography},
  year={1983},
  volume={277},
  pages={
          79-85
        }
}
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Data are consistent with the concept that delta 1-testololactone is a potent inhibitor of peripheral aromatization of delta to E1, which could explain the antitumor properties of this compound.
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The hypothesis that T or one of its metabolites can modulate LH and FSH secretion independently of peripheral aromatization to E is supported, as well as the pattern of plasma steroids, increased T and unchanged E.
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The data suggest that Teslac may be an effective treatment for men with idiopathic oligospermia, and a potent inhibitor of conversion of androgens to estrogens.
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