Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells.

@article{Yi2001QuantitationOT,
  title={Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells.},
  author={X. Yi and J. Shay and W. Wright},
  journal={Nucleic acids research},
  year={2001},
  volume={29 23},
  pages={
          4818-25
        }
}
Telomerase is a reverse transcriptase that adds telomeric repeats to chromosomal ends. In most normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to limited proliferative life-span. Telomerase reactivation is associated with cellular immortalization and is a frequent event during tumorigenesis. The telomerase ribonucleoprotein complex consists of two essential components, a catalytic protein subunit [human telomerase reverse transcriptase (hTERT… Expand
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