Quantitation of sirolimus using liquid chromatography-tandem mass spectrometry (LC-MS-MS).


A multiple reaction monitoring positive ion HPLC method with tandem mass spectrometric detection (MS-MS) for determination of sirolimus in human blood samples is described. This method utilizes an online cleanup step that provides simple and rapid sample preparation with a switching valve technique. This procedure includes: instrumentation, API 3000 triple… (More)
DOI: 10.1007/978-1-60761-459-3_46


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