Quantitation of human peptides and proteins via MS: review of analytically validated assays.

@article{Chappell2014QuantitationOH,
  title={Quantitation of human peptides and proteins via MS: review of analytically validated assays.},
  author={Derek L. Chappell and Michael E. Lassman and Thomas A McAvoy and Mingxiang Lin and Daniel S. Spellman and Omar F. Laterza},
  journal={Bioanalysis},
  year={2014},
  volume={6 13},
  pages={1843-57}
}
Since the development of monoclonal antibodies in the 1970s, antibody-based assays have been used for the quantitation of proteins and peptides and, today, they are the most widely used technology in routine laboratory medicine and bioanalysis. However, in the last couple of decades, liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) techniques have been adopted in the quantitation of small molecules, and more recently have made significant contributions in the quantitation of… CONTINUE READING

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