Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR.

@article{Punia2004QuantitationOH,
  title={Quantitation of hepatitis B lamivudine resistant mutants by real-time amplification refractory mutation system PCR.},
  author={Parvinder Punia and Patricia Cane and Chong-Gee Teo and Nicholas A. Saunders},
  journal={Journal of hepatology},
  year={2004},
  volume={40 6},
  pages={986-92}
}
BACKGROUND/AIMS Lamivudine is an antiviral drug that is used to treat hepatitis B virus (HBV) infection. Long-term therapy does not completely suppress viral replication, and resistant mutants emerge. Resistance is mediated by changes in the tyrosine-methionine-apartate-aspartate (YMDD) motif in the catalytic site of the HBV polymerase gene. We describe a method to detect and quantify mutant viral populations using amplification refractory mutation system (ARMS) PCR. METHODS We developed a… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…