Quantitation of haemagglutinin in H5N1 influenza viruses reveals low haemagglutinin content of vaccine virus NIBRG-14 (H5N1).

@article{Harvey2008QuantitationOH,
  title={Quantitation of haemagglutinin in H5N1 influenza viruses reveals low haemagglutinin content of vaccine virus NIBRG-14 (H5N1).},
  author={Ruth Harvey and Jun X. Wheeler and Chantal L Wallis and J. Ian S. Robertson and Othmar G Engelhardt},
  journal={Vaccine},
  year={2008},
  volume={26 51},
  pages={6550-4}
}
The assessment of potential candidate influenza vaccine viruses includes a number of factors. Growth properties of the virus and yield of antigen, specifically the haemagglutinin (HA), are of key importance. The recently developed H5N1 candidate vaccine virus NIBRG-14 (with HA and NA genes derived from the clade 1 virus A/Viet Nam/1194/2004 in an A/Puerto Rico/8/34 background) has been suggested to yield low amounts of antigen. While investigating the antigen yield of H5N1 vaccine viruses, we… CONTINUE READING

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