Quantitation of cocaine and its major metabolites in human saliva using gas chromatography-positive chemical ionization-mass spectrometry (GC-PCI-MS).

@article{Cmpora2003QuantitationOC,
  title={Quantitation of cocaine and its major metabolites in human saliva using gas chromatography-positive chemical ionization-mass spectrometry (GC-PCI-MS).},
  author={Pamela C{\'a}mpora and Ana Mar{\'i}a Bermejo and Mar{\'i}a Jes{\'u}s Tabernero and Purificaci{\'o}n Fern{\'a}ndez},
  journal={Journal of analytical toxicology},
  year={2003},
  volume={27 5},
  pages={270-4}
}
An analytical method for the simultaneous determination of cocaine (COC) and its major metabolites, ecgonine methyl ester (EME) and benzoylecgonine (BEG), in saliva was developed. The method involves liquid-liquid extraction in Toxitubes A, derivatization with 99:1 (v/v) N,O-bis-trimethylsilyltrifluoroacetamide (BSTFA)/trimethylchlorosilane (TMCS) and gas… CONTINUE READING