Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography.

@article{Hume1992QuantitationOC,
  title={Quantitation of carbon-11-labeled raclopride in rat striatum using positron emission tomography.},
  author={S. P. Hume and Ralph Myers and Peter M. Bloomfield and Jolanta Opacka-Juffry and Jill E. Cremer and R. G. Ahier and Sajinder K. Luthra and David J. Brooks and Adriaan A. Lammertsma},
  journal={Synapse},
  year={1992},
  volume={12 1},
  pages={47-54}
}
Using conventional autoradiographic and tissue counting techniques, the experimental quantitation of in vivo kinetics of prospective or established radioligands for PET is animal and labour intensive. The present study tested the feasibility of using PET itself to quantitate the specific binding of [11C]raclopride to rat striatum and to study the effects of experimental manipulation of endogenous dopamine on binding parameters. Carbon-11-labeled raclopride was given i.v. to anaesthetised rats… CONTINUE READING