Quantitation of benzodiazepine receptors in human brain using the partial saturation method.

@article{Delforge1996QuantitationOB,
  title={Quantitation of benzodiazepine receptors in human brain using the partial saturation method.},
  author={Jacques Delforge and L Spelle and Bernard Bendriem and Yves Samson and Michel Bottlaender and Sotirios Papageorgiou and Andr{\'e} Syrota},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1996},
  volume={37 1},
  pages={
          5-11
        }
}
UNLABELLED The in vivo quantification of the benzodiazepine receptor concentration in humans using PET and flumazenil (FMZ) is usually based on Scatchard analysis when the goal is to avoid blood sampling. The experimental protocols, however, include several (at least two) experiments with various specific activities in the same subject to obtain a range of bound ligand concentrations. METHODS We propose the partial saturation method, which is based on a natural decrease in bound ligand… CONTINUE READING
Highly Cited
This paper has 24 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Anatomic and biochemical correlates of the dopamine transporter ligand 11C-PE2I in normal and parkinsonian primates: comparison with 6-[18F]fluoro-L-dopa.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 2001
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 1995
View 8 Excerpts
Highly Influenced

Modeling analysis of [11C]flumazenil kinetics studied by PET: application to a critical study of the equilibrium approaches.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 1993
View 8 Excerpts
Highly Influenced

Concept of reaction volume in the in vivo ligand-receptor model.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine • 1996
View 2 Excerpts

Fast nonsupervised three-dimensional registration of PET and MR images of the brain

J. Lopez-Krähe
J Cereb Blood Flov.- Metab • 1994

Measurement of benzodiazepine receptor number and affinity in humans using tracer kinetic modeling, positron emission tomography, and [11C]flumazenil.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism • 1993
View 3 Excerpts

Quantification of benzodiazepine receptors in vivo using "C-flumazenil: application of the steady state principle

A Lammertsma, M Lassen N. Prevett
1993
View 2 Excerpts

Central benzopiazepinc receptors in human brain: estimation of regional BIllas and Kd values with positron emission tomography

JC Abadie P. Baron JC. Bisserbe
Eur J Pharmacol • 1992
View 3 Excerpts

Evaluation of a PET scanner in two-dimensional and three-dimensional acquisition

B Bendriem, V Trebossen R. Frouin, O Lamer, V Brulon, A. Syrota
Moucci JP. Plonsey R. Coatrieux JL. Laxminarayan S, eds. Proceedings of ¡heannual international conference of the IEEE Engineering in Medicine and Biology Society • 1992