Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole time-of-flight tandem mass spectrometry.

@article{Nieuwerburgh2006QuantitationOA,
  title={Quantitation of artemisinin and its biosynthetic precursors in Artemisia annua L. by high performance liquid chromatography-electrospray quadrupole time-of-flight tandem mass spectrometry.},
  author={Filip Van Nieuwerburgh and Sofie R F Vande Casteele and Lies Maes and Alain Goossens and Dirk Inz{\'e} and Jan F P Van Bocxlaer and Dieter L.D. Deforce},
  journal={Journal of chromatography. A},
  year={2006},
  volume={1118 2},
  pages={180-7}
}
This study reports the development and validation of a rapid, sensitive and selective assay for the quantitation of artemisinin, arteannuin B, artemisitene and artemisinic acid in Artemisia annua L. by reversed phase high performance liquid chromatography (HPLC) electrospray (ESI) quadrupole time of flight (Q-TOF) tandem mass spectrometry (MS/MS). A recovery of >97% for all analytes was achieved by immersing one gram of fresh plant material in chloroform for 1 min. This result supports the… CONTINUE READING

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