Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

@article{Harding1990QuantitationOA,
  title={Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation},
  author={Clifford V Harding and Emil R Unanue},
  journal={Nature},
  year={1990},
  volume={346},
  pages={574-576}
}
THE number of specific complexes formed between peptide and the class II major histocompatibility complex (MHC) molecules expressed by an antigen-presenting cell (APC) after exposure to protein antigens is unknown, as is the number that activates T cells. Presentation of foreign peptides by APC takes place when many class II molecules may be occupied by autologous peptides1–3. We have now estimated the number of specific peptide/class II complexes per APC by quantitative immunoprecipitation of… CONTINUE READING

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