Quantitation of Propofol Metabolite, 2,6-Diisopropyl-1,4-quinol, by Gas Chromatography-Mass Spectrometry

@inproceedings{Guitton1997QuantitationOP,
  title={Quantitation of Propofol Metabolite, 2,6-Diisopropyl-1,4-quinol, by Gas Chromatography-Mass Spectrometry},
  author={J. Guitton and T. Burronfosse and Muriel Sanchez and Michel D{\'e}sage},
  year={1997}
}
Abstract Propofol is an intravenous anaesthetic widely used for induction and maintenance of anaesthesia and for sedation. A sensitive and simple gas chromatography-mass spectrometry (GC-MS) method for the determination of 2,6-diisopropyl-1,4-quinol, the major hydroxylated propofol metabolite, is presented. Thymol was used as internal standard. Thymol and 2,6-diisopropyl-1,4-quinol are extracted under basic conditions. The extraction efficiencies for quinol metabolite was > 90 %. Standard… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-9 OF 9 CITATIONS

Propofol hydroxylation by dog liver microsomes: assay development and dog breed differences.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 1999
VIEW 4 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Expression of CYP1A1 and CYP1A2 in the liver and kidney of rabbits after prolonged infusion of propofol.

  • Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2016