Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.

@article{Callaway1996QuantitationON,
  title={Quantitation of N,N-dimethyltryptamine and harmala alkaloids in human plasma after oral dosing with ayahuasca.},
  author={James C. Callaway and Lionel P. Raymon and William Lee Hearn and Dennis J. Mckenna and Charles S. Grob and Glacus S. Brito and D C Mash},
  journal={Journal of analytical toxicology},
  year={1996},
  volume={20 6},
  pages={
          492-7
        }
}
Harmine, harmaline, tetrahydroharmine (THH), and N,N-dimethyltryptamine (DMT) were quantitated in plasma from 15 healthy male volunteers after the ingestion of ayahuasca, a beverage that has been used for religious purposes in Brazil since pre-Columbian times. A growing awareness of the interest in this ancient shamanistic practice in modern urban cultures and the widespread popular dissemination of the inebriant effects and type and sources of the plant admixtures used to prepare the beverage… 
Pharmacokinetics of Hoasca alkaloids in healthy humans.
TLDR
N,N-Dimethyltryptamine, harmine, harmaline and tetrahydroharmine are the characteristic alkaloids found in Amazonian sacraments known as hoasca, ayahuasca, and yajè and little is known of their pharmacokinetics.
Determination of N,N-dimethyltryptamine and beta-carboline alkaloids in human plasma following oral administration of Ayahuasca.
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    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  • 2002
TLDR
The gas chromatography and HPLC methods described allowed adequate characterization of the pharmacokinetics of the four main alkaloids present in ayahuasca, and also of two major beta-carboline metabolites not previously described in the literature.
Gas chromatographic analysis of dimethyltryptamine and beta-carboline alkaloids in ayahuasca, an Amazonian psychoactive plant beverage.
TLDR
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TLDR
The method proved to be simple, rapid and useful to estimate administered doses for further pharmacological and toxicological investigations of ayahuasca exposure and improved at the lower end of the calibration curve.
Kinetic profile of N,N-dimethyltryptamine and β-carbolines in saliva and serum after oral administration of ayahuasca in a religious context.
TLDR
The possibility of using saliva as a biological matrix to detect DMT, β-carbolines and their derivatives is very interesting since it allows fast non-invasive sample collection and could be useful for detecting similar alkaloids used recreationally that have considerable potential for intoxication.
Stability Evaluation of DMT and Harmala Alkaloids in Ayahuasca Tea Samples
TLDR
Although DMT has proven to be stable in all studied conditions, the harmala alkaloids revealed intense degradation and even concentration increment, which may be caused by degradation, alkaloid inter-conversion, and leaching from tea precipitate material.
Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
TLDR
The toxicokinetics and toxicodynamics of the psychoactive DMT and harmala alkaloids harmine, harmaline and tetrahydroharmine, are comprehensively covered, particularly emphasizing the psychological, physiological, and toxic effects deriving from their concomitant intake.
Methodology for determining major constituents of ayahuasca and their metabolites in blood.
TLDR
A single methodology is reported here a single methodology for the direct analysis of 14 of the major alkaloid components of ayahuasca, including several known and potential metabolites of N,N-dimethyltryptamine and the harmala alkaloids in blood.
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TLDR
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Determination of potentially hallucinogenic N-dimethylated indoleamines in human urine by HPLC/ESI-MS-MS.
TLDR
The bufotenine excretion of psychiatric patients was found to be higher than that of the somatic patients, and the dimethylated amines were found in significant amounts.
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The levels of DMT and beta-carbolines found in the ayahuasca samples examined in the present study were an order of magnitude greater than the levels reported in a previous study, which indicated that their effects in combination are additive, rather than synergistic or antagonistic.
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