Quantitation of HERV-K env gene expression and splicing in human breast cancer

@article{WangJohanning2003QuantitationOH,
  title={Quantitation of HERV-K env gene expression and splicing in human breast cancer},
  author={Feng Wang-Johanning and Andra R. Frost and Bixi Jian and Lidia Epp and Danielle W Lu and Gary Johanning},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={1528-1535}
}
Human endogenous retroviruses (HERVs) comprise up to 8% of the human genome. In previous studies, we demonstrated that type 1 HERV-K envelope (env) transcripts are expressed in most human breast cancers, but not in normal breast tissues. In the current study, we report that type 2 HERV-K env transcripts are also present in human breast cancers. By real-time RT–PCR, the expression of HERV-K env transcripts was 5–10-fold higher in breast cancer cell lines treated with estradiol and progesterone… CONTINUE READING