Quantitation of DNA methylation in Epstein-Barr virus–associated nasopharyngeal carcinoma by bisulfite amplicon sequencing

@article{Zhao2017QuantitationOD,
  title={Quantitation of DNA methylation in Epstein-Barr virus–associated nasopharyngeal carcinoma by bisulfite amplicon sequencing},
  author={Weilin Zhao and Yingxi Mo and Shumin Wang and Kaoru Midorikawa and Ning Ma and Yusuke Hiraku and Shinji Oikawa and Guangwu Huang and Zhe Zhang and Mariko Murata and Kazuhiko Takeuchi},
  journal={BMC Cancer},
  year={2017},
  volume={17}
}
BackgroundEpigenetic changes, including DNA methylation, disrupt normal cell function, thus contributing to multiple steps of carcinogenesis. Nasopharyngeal carcinoma (NPC) is endemic in southern China and is highly associated with Epstein-Barr virus (EBV) infection. Significant changes of the host cell methylome are observed in EBV-associated NPC with cancer development. Epigenetic marks for NPC diagnosis are urgently needed. In order to explore DNA methylation marks, we investigated DNA… 
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