Quantitation of Alzheimer's amyloid peptide and identification of related amyloid proteins by dot-blot immunoassay.

@article{Permanne1995QuantitationOA,
  title={Quantitation of Alzheimer's amyloid peptide and identification of related amyloid proteins by dot-blot immunoassay.},
  author={Bruno Permanne and Luc Bu{\'e}e and Jean Philippe David and Catherine Fallet-Bianco and Claude Di Menza and Andr{\'e} Delacourte},
  journal={Brain research},
  year={1995},
  volume={685 1-2},
  pages={154-62}
}
In Alzheimer's disease, the main component of amyloid deposits is a 39-43 amino acid peptide referred to as amyloid peptide or A beta. A crucial issue in the study of this disorder is to define the sequence of events that lead to amyloid deposition. In the present study, a new approach was developed that allows to specifically solubilize A beta peptide trapped within amyloid deposits and to quantify its amount by dot-blot immunoassay. The present method also permits to isolate components… CONTINUE READING

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