Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells

@article{Stick1983QuantitatingTS,
  title={Quantitating the synergistic effect of smoking and alcohol consumption with the micronucleus test on human buccal mucosa cells},
  author={H. Stick and M. Rosin},
  journal={International Journal of Cancer},
  year={1983},
  volume={31}
}
The micronucleus test was applied to exfoliated cells of the buccal mucosa of four population groups: (A) non‐smokers and non‐drinkers of alcoholic beverages, (B) non‐smokers but alcohol drinkers, (C) smokers but non‐drinkers, and (D) smokers and drinkers. An elevated frequency of micronucleated buccal mucosa cells was observed only in group D (smokers and alcohol drinkers). When group D was subdivided according to the number of cigarettes smoked, the frequency of micronucleated buccal cells… Expand
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References

SHOWING 1-10 OF 12 REFERENCES
Application of the micronucleus test to exfoliated cells of high cancer risk groups: Tobacco chewers
TLDR
The micronucleus test on exfoliated cells can provide evidence of carcinogen exposure in the tissue from which cancers will develop, and combines all the advantages of in vitro short‐term tests for genotoxic and carcinogenic agents with those of using an intact organism with all its defence mechanisms. Expand
Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: betel quid chewers.
TLDR
Micronuclei frequencies in exfoliated human cells seem to represent a useful 'internal dosimeter' for estimating exposure to genotoxic, and by implication, carcinogenic agents in the tissue from which cancers will develop. Expand
Alcohol as a co‐factor in the etiology of cancer
TLDR
Because primary hepatocellular carcinoma occurs more commonly in patients with cirrhosis, chronic alcohol abuse is an important risk mechanism for carcinoma of the liver parenchyma. Expand
ADAPTATION OF THE DNA‐REPAIR AND MICRONUCLEUS TESTS TO HUMAN CELL SUSPENSIONS AND EXFOLIATED CELLS *
TLDR
In vitro tests, which lack the complete metabolic activation and inactivation systems of a whole organism, may predict a potential but not the actual carcinogenic hazard to man. Expand
Etiological and preventive implications in alcohol carcinogenesis.
TLDR
Data are presented which indicate that in vitro metabolism of the hepatocarcinogen N-nitrosopyrrolidine is increased in microsomal fractions isolated from ethanol-consuming hamsters, which could account for the increased risk of cancer in heavy drinkers who smoke. Expand
Measurements of drinking patterns in the general population and possible applications in studies of the role of alcohol in cancer.
TLDR
It is suggested that measurement will need to extend beyond volume of drinking and may indeed involve studies of new kinds of dimensions in the patterning of drinking. Expand
The Micronucleus Assay. I. In Vivo
TLDR
The micronucleus assay was developed to detect in vivo chromosomal breakage more easily than traditional cytogenetic techniques and has largely replaced the traditional scoring of metaphases in bone marrow cells. Expand
The DNA content of micronuclei induced in mouse bone marrow by gamma-irradiation: evidence that micronuclei arise from acentric chromosomal fragments.
TLDR
The DNA contents of 75 micronuclei found in mouse bone marrow 48 h after a 260 R dose of gamma-rays were measured individually and compared to 71 diploid G1 nuclei and were in agreement with the expectations based upon the hypothesis that micron nuclei arise from acentric chromosomal fragments produced by random breakage of the mouse genome. Expand
Diet in the epidemiology of oral cancer.
In this comparison of 425 oral cancer patients and 588 controls, it was found that risk increased in dose‐response fashion as vitamin A or vitamin C intake decreased. This elevation of relative riskExpand
Persons at high risk of cancer.
  • A. Knudson
  • Medicine
  • The New England journal of medicine
  • 1979
The remarkable family study of renal carcinoma reported in this issue of the Journal provides us with the first example of a dominantly inherited chromosomal aberration that imposes a high risk of aExpand
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