Quantifying tumor-selective radiation dose enhancements using gold nanoparticles: a monte carlo simulation study.

@article{Zhang2009QuantifyingTR,
  title={Quantifying tumor-selective radiation dose enhancements using gold nanoparticles: a monte carlo simulation study.},
  author={Sean Zhang and Junfang Gao and Thomas A. Buchholz and Zhonglu Wang and Mohammad R. Salehpour and Rebekah A. Drezek and T C Yu},
  journal={Biomedical microdevices},
  year={2009},
  volume={11 4},
  pages={925-33}
}
Gold nanoparticles can enhance the biological effective dose of radiation delivered to tumors, but few data exist to quantify this effect. The purpose of this project was to build a Monte Carlo simulation model to study the degree of dose enhancement achievable with gold nanoparticles. A Monte Carlo simulation model was first built using Geant4 code. An Ir-192 brachytherapy source in a water phantom was simulated and the calculation model was first validated against previously published data… CONTINUE READING