Quantifying the sequence-dependent species barrier between hamster and mouse prions.

@article{Lee2007QuantifyingTS,
  title={Quantifying the sequence-dependent species barrier between hamster and mouse prions.},
  author={Lily Y-L Lee and Rita P-Y Chen},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 6},
  pages={1644-52}
}
Prion diseases are transmissible neurodegenerative disorders. It is widely accepted that prions are the infectious agents responsible for disease transmission, and the sequence homology between the infectious prion and the host prion protein determines its transmission efficiency across species. However, previous studies have often reported different results regarding seeding efficiency, the efficiency of initiating amyloid propagation by adding pre-existing amyloid fibrils as seed. In the… CONTINUE READING

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