• Corpus ID: 231861859

Quantifying the relative contribution of free virus and cell-to-cell transmission routes to the propagation of hepatitis C virus infections in vitro using an agent-based model

@inproceedings{Blahut2021QuantifyingTR,
  title={Quantifying the relative contribution of free virus and cell-to-cell transmission routes to the propagation of hepatitis C virus infections in vitro using an agent-based model},
  author={Kenneth Blahut and Christian Quirouette and Jordan J. Feld and Shingo Iwami and Catherine A. A. Beauchemin},
  year={2021}
}
Experiments have shown that hepatitis C virus (HCV) infections in vitro disseminate both distally via the release and diffusion of cell-free virus through the medium, and locally via direct, cell-to-cell transmission. To determine the relative contribution of each mode of infection to HCV dissemination, we developed an agent-based model (ABM) that explicitly incorporates both distal and local modes of infection. The ABM tracks the concentration of extracellular infectious virus in the… 
Choice of spatial discretisation influences the progression of viral infection within multicellular tissues
TLDR
It is shown that the resolution of spatial discretisation modulates the timescale of infection, and identified the mechanisms by which this occurs, and provides theory to inform the development of multicellular models of viral dynamics, which is in short supply in the literature.

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