Quantifying the impact of drug-drug interactions associated with opioids.

  title={Quantifying the impact of drug-drug interactions associated with opioids.},
  author={J V Pergolizzi},
  journal={The American journal of managed care},
  volume={17 Suppl 11},
Opioids have long been the mainstay of pain control for patients with cancer; however, their use in patients with chronic, moderate to severe pain has increased greatly in the past decade. The risk of drug-drug interactions (DDIs) is a concern with all medications, but is of particular concern in patients using opioids. Most opioids are metabolized via the cytochrome P450 enzyme system, the same system that metabolizes more than half of all prescription medications. Pharmacokinetic (PK) DDIs… CONTINUE READING
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